## Abstract The microbial toxin okadaic acid (OA) specifically inhibits PPP‐type ser/thr protein phosphatases. OA is an established tumor promoter with numerous cellular effects that include p53‐mediated cell cycle arrest. In T51B rat liver epithelial cells, a model useful for tumor promotion studi
Inhibition of cell-cell communication by methylsulfonyl metabolites of polychlorinated biphenyl congeners in rat liver epithelial IAR 20 cells
✍ Scribed by Yoshihisa Kato; Kerstin Kenne; Koichi Haraguchi; Yoshito Masuda; Ryohei Kimura; Lars Wärngård
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 343 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0340-5761
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We found that a rat liver epithelial cell line (IAR 20) expresses connexin 43, the major cardiac gap-junction protein, but not connexin 26 or connexin 32, major liver gap-junction proteins. The effects of TPA on connexin 43 expression in IAR 20 were investigated using northern blot analysis, western
Gap junctional communication (GJC) between contacting cells has been postulated to be involved in the regulation of cell proliferation. This suggestion stems from numerous studies showing modulation of GJC by agents that influence cellular proliferation. Platelet-derived growth factor (PDGF), a stro