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Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog

✍ Scribed by James K. Coward; Maria D'Urso-Scott; William D. Sweet


Book ID
115771176
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
294 KB
Volume
21
Category
Article
ISSN
0006-2952

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Inhibition of human erythrocyte and gast
✍ E. Schultz; S. Tarpila; A.-C. BΓ€ckstrΓΆm; A. Gordin; E. Nissinen; P. Pohto πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 367 KB

The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases