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Inhibition of catalase and epoxide hydrolase by the renal cystogen 2-amino-4,5-diphenylthiazole and its metabolites

✍ Scribed by J Thomas Hjelle; Thomas M Guenthner; Kevin Bell; Robert Whalen; George Flouret; Frank A Carone

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
645 KB
Volume
60
Category
Article
ISSN
0300-483X

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## 2-Amino -1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine found in cooked meat. It is metabolically activated by the human cytochrome P450 enzymes to form the carcinogenic metabolite N 2 -OH-PhIP. PhIP has been found to induce tumors in rats and is