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Inhibition of carcinogenesis in transgenic mouse models over-expressing 15-lipoxygenase in the vascular wall under the control of murine preproendothelin-1 promoter

✍ Scribed by Dror Harats; Dikla Ben-Shushan; Hofit Cohen; Ayelet Gonen; Iris Barshack; Iris Goldberg; Shoshana Greenberger; Israel Hodish; Ayelet Harari; Nira Varda-Bloom; Keren Levanon; Ehud Grossman; Pavlos Chaitidis; Hartmut Kühn; Aviv Shaish

Book ID: 116333647
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 371 KB
Volume: 229
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2005.02.017

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✍ Rosalind A. Graham; Joanna R. Morris; Edward P. Cohen; Joyce Taylor-Papadimitrio 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 673 KB

In this study we examined the regulation of expression of the human MUC1 gene in vivo, by developing MUC1 transgenic mice. The data showed that epithelial-specific expression of MUC1 can be directed by just 1.4 kb of 5' flanking sequence using MUC1 cDNA as a reporter gene in vivo. Furthermore, high