Inhibition of canine parvovirus replication in cultured cells by small interfering RNAs expressed from plasmid vectors
โ Scribed by Ying He; Wangbin Cao; Sumin Pan; Fei Zhong; Manfu Zhang
- Book ID
- 119190600
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 495 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0166-3542
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## Abstract ## Background There has been much research into the use of RNA interference (RNAi) for the treatment of human diseases. Many viruses, including hepatitis B virus (HBV), are susceptible to inhibition by this mechanism. However, for RNAi to be effective therapeutically, a suitable delive
Vector-based RNA interference (RNAi) has attracted great interest, because of its more prolonged gene silencing effect compared with small interfering RNA (siRNA). However, the intensity and duration of vector-based RNAi effect has received little attention. In this study, the gene silencing kinetic