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Inhibition of Bacterial Peptide Deformylase by Biaryl Acid Analogs

โœ Scribed by Barbara Gordon Green; Jeffrey H. Toney; John W. Kozarich; Stephan K. Grant

Book ID
115568079
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
73 KB
Volume
375
Category
Article
ISSN
0003-9861

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๐Ÿ“œ SIMILAR VOLUMES

Inhibition and Structure-Activity Studie
Inhibition and Structure-Activity Studies of Methionine Hydroxamic Acid Derivatives with Bacterial Peptide Deformylase
โœ Stephan K. Grant; Barbara Gordon Green; John W. Kozarich ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 257 KB

The posttranslational deformylation of N-formyl-Met-polypeptides by the metalloenzyme, peptide deformylase, is essential for bacterial growth. Methionine hydroxamic acid derivatives were found to inhibit recombinant Escherichia coli peptide deformylase activity containing either zinc or cobalt. The