Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10

Restoration of central nervous system α-

Restoration of central nervous system α-N-acetylglucosaminidase activity and therapeutic benefits in mucopolysaccharidosis IIIB mice by a single intracisternal recombinant adeno-associated viral type 2 vector delivery

✍ Haiyan Fu; Julianne DiRosario; Lu Kang; Joseph Muenzer; Douglas M. McCarty 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB

## Abstract ## Background Finding efficient central nervous system (CNS) delivery approaches has been the major challenge facing therapeutic development for treating diseases with global neurological manifestation, such as mucopolysaccharidosis (MPS) IIIB, a lysosomal storage disease, caused by au