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Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C

✍ Scribed by R. W. Randall; K. E. Eakins; G. A. Higgs; J. A. Salmon; J. E. Tateson


Publisher
SP Birkhäuser Verlag Basel
Year
1980
Tongue
English
Weight
230 KB
Volume
10
Category
Article
ISSN
1420-908X

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The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (