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Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis of Murine Osteosarcoma

✍ Scribed by Virna D. Leaner; Jeffrey F. Chick; Howard Donninger; Ilona Linniola; Arnulfo Mendoza; Chand Khanna; Michael J. Birrer


Book ID
117970838
Publisher
American Society for Investigative Pathology
Year
2009
Tongue
English
Weight
722 KB
Volume
174
Category
Article
ISSN
0002-9440

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Bone cells are a prime target for the biological function of the fos/jun (activating protein-1 (AP-1)) transcription factor complex. Deregulated expression of c-fos or v-fos in bone cells induces tumorigenicity and the formation of non-metastatic osteosarcomas. In contrast, fos oncogenes transform f