✦ LIBER ✦

Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa

✍ Scribed by Hyun Sun Lee; Won Keun Oh; Hee Cheol Choi; Jun Won Lee; Dae Ook Kang; Chan Sun Park; Tae-Ick Mheen; Jong Seog Ahn

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 91 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199805)12:3<212::aid-ptr216>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

A biologically monitored fractionation of methanol extracts of the fruit of Evodia rutaecarpa led to the isolation of quinolone alkaloids, evocarpin (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3) as blockers of angiotensin II receptor binding with IC 50 values of 43.4 mM, 34.1 mM and 48.2 mM, respectively.