Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in Brown-Norway rats

Inhibition of Antigen-induced Pulmonary

Inhibition of Antigen-induced Pulmonary Eosinophilia and Neutrophilia by Selective Inhibitors of Phosphodiesterase Types 3 or 4 in Brown Norway Rats

✍ R.E. Howell; L.P. Jenkins; L.E. Fielding; D. Grimes 📂 Article 📅 1995 🏛 Elsevier 🌐 English ⚖ 446 KB

SUMMARY: Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting that PDE4-selective inhibitors could be useful for treating asthma. Although the rat is used extensively in preclin