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Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia

✍ Scribed by Edward L. Schwartz; Steven Hallam; Robert E. Gallagher; Peter H. Wiernik

Book ID
115784340
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
740 KB
Volume
50
Category
Article
ISSN
0006-2952

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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A