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Inhibition of Agonist-Induced Ca2+Entry in Endothelial Cells by Myosin Light-Chain Kinase Inhibitor

✍ Scribed by Hiroshi Watanabe; Reiko Takahashi; Xu-Xia Zhang; Hiroyasu Kakizawa; Hideharu Hayashi; Ryuzo Ohno


Book ID
115578920
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
103 KB
Volume
225
Category
Article
ISSN
0006-291X

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Effects of a myosin light chain kinase i
✍ Makoto Takayama; Hiroshi Ozaki; Hideaki Karaki πŸ“‚ Article πŸ“… 1996 πŸ› Springer-Verlag 🌐 English βš– 870 KB

Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat