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Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)

✍ Scribed by Gakuji Hashimoto; Takanori Aoki; Hiroyuki Nakamura; Kazuhiko Tanzawa; Yasunori Okada

Book ID: 117102888
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 162 KB
Volume: 494
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(01)02323-7

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## Abstract The tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1) has been recognized as a multifunctional protein. The role of TIMPs in cancer remains the subject of conflicting reports with an antitumor activity or a tumor growth stimulation activity by several mechanisms. The aim of our s