Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
✍ Scribed by Y. Luan; L. Kong; D.R. Howell; K. Ilalov; M. Fajardo; X.-H. Bai; P.E. Di Cesare; M.B. Goldring; S.B. Abramson; C.-J. Liu
- Book ID
- 113732792
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 453 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1063-4584
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## Abstract ## Objective To determine 1) whether a protein interaction network exists between granulin‐epithelin precursor (GEP), ADAMTS‐7/ADAMTS‐12, and cartilage oligomeric matrix protein (COMP); 2) whether GEP interferes with the interactions between ADAMTS‐7/ADAMTS‐12 metalloproteinases and CO
Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti