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Inhibition of activities of DNA polymerase α, β, γ, and reverse transcriptase of L1210 cells by phosphonoacetic acid

✍ Scribed by H.S. Allaudeen; J.R. Bertino


Book ID
115746941
Publisher
Elsevier Science
Year
1978
Weight
425 KB
Volume
520
Category
Article
ISSN
0005-2787

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Differential inhibition of DNA polymeras
✍ Miriam Margalith; Haya Falk; Amos Panet 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 439 KB

Three potential inhibitors of reverse transcriptase activities, phosphonoformate (PF), phosphonoacetate (PAA), and ethyl-diethyl phosphonoformate (Et-PF), were compared in this study. Only PF was found to inhibit the DNA polymerase activity of the purified reverse transcriptase of Moloney murine leu