𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibition of acid-induced decomposition of diphenyltriazenes by complexation with cyclodextrins

✍ Scribed by Tingting Xu; Atefeh Vaez-Zadeh Asadi; Mónica Barra

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
538 KB
Volume
42
Category
Article
ISSN
0538-8066

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Acid‐promoted NN bond cleavage in 1,3‐diphenyltriazenes (X‐Ph‐N=N‐NH‐Ph‐X; X = H, 4‐OCH~3~), leading to formation of diazonium ions and anilines, is strongly inhibited in aqueous solutions in the presence of cyclodextrins (CDs). The inhibition is ascribed to the formation of inclusion complexes that render the guest diphenyltriazene significantly less basic as a result of the less polar nature of the CD cavity (a microsolvent effect). Association equilibrium constants for 1:1 host–guest complexes increase in the order α‐CD <β‐CD ∼ permethyl‐β‐CD < hydroxypropyl‐β‐CD, with values for X = 4‐OCH~3~ being larger than those for X = H. In the case of α‐CD, formation of 2:1 host–guest complexes is also involved. © 2010 Wiley Periodicals, Inc. Int J Chem Kinet 42: 567–574, 2010

📜 SIMILAR VOLUMES

Reduction of bitterness of antihistamini
Reduction of bitterness of antihistaminic drugs by complexation with β-cyclodextrins
✍ Nao Ono; Yuji Miyamoto; Takako Ishiguro; Keiichi Motoyama; Fumitoshi Hirayama; D 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 546 KB

Reduction of bitterness of antihistaminic drugs by cyclodextrin (CyD) complexation was examined. The stability constant (Kc) of the 1:1 CyD inclusion complexes with antihistaminic drugs increased in the order of 2-hydroxypropyl-β-CyD (HP-β-CyD) ≈ β-CyD > γ-CyD > α-CyD for diphenhydramine and epinast

Inhibition of phenylephrine-induced card
Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid
✍ Rafat A. Siddiqui; Saame Raza Shaikh; Richard Kovacs; William Stillwell; Gary Za 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 782 KB

## Abstract Many of the cardiovascular benefits of fish oil result from the antiarrhythmic actions of the n‐3 polyunsaturated lipids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). The beneficial effects of DHA/EPA in patients with coronary artery disease and myocardial infarction may a

Inhibition of agitation-induced aggregat
Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-β-cyclodextrin
✍ Tim Serno; John F. Carpenter; Theodore W. Randolph; Gerhard Winter 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 280 KB

In order to provide an alternative to nonionic surfactants as excipients for protein formulations, cyclodextrin-derivatives (CDs) were examined for their potential to inhibit agitation-induced aggregation of an IgG in aqueous solution. Loss of monomeric protein and protein aggregation were monitored