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Inhibition of 5-lipoxygenase activity by the natural anti-inflammatory compound aethiopinone

✍ Scribed by R. Benrezzouk; M.C. Terencio; M.L. Ferrandiz; M. Hernandez-Perez; R. Rabanal; M.J. Alcaraz

Publisher
SP Birkhäuser Verlag Basel
Year
2001
Tongue
English
Weight
99 KB
Volume
50
Category
Article
ISSN
1420-908X

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Improvement of dissolution and oral abso
Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion
✍ Ikuo Kushida; Masaki Ichikawa; Naoki Asakawa 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

Several formulation approaches were attempted to improve the dissolution and the oral absorption of ER-34122, which is a novel dual 5-lipoxygenase/ cyclooxygenase inhibitor with potent anti-in¯ammatory activity. The solid dispersion of ER-34122 with hydroxypropylmethylcellulose (TC-5RW), which is an