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Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogs of the investigational chemotherapeutic drug 4-ipomeanol

✍ Scribed by Lin, Jyh Ming; Desai, Dhimant H.; Morse, Mark A.; Amin, Shantu; Hecht, Stephen S.


Book ID
126154445
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
804 KB
Volume
5
Category
Article
ISSN
0893-228X

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## Abstract Urinary metabolites of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di