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Inhibition kinetics and selectivity of the tyrosine kinase inhibitor erbstatin and a pyridone-based analogue

✍ Scribed by Chin-Yi Jenny Hsu; Mary V. Jacoski; Martin P. Maguire; Alfred P. Spada; Asher Zilberstein


Book ID
115782803
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
958 KB
Volume
43
Category
Article
ISSN
0006-2952

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Pyranone, Thiopyranone, and Pyridone Inh
The tyrosine kinase inhibitor dasatinib
✍ Kate Vandyke; Andrea L Dewar; Peter Diamond; Stephen Fitter; Christopher G Schul πŸ“‚ Article πŸ“… 2010 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 423 KB

## Abstract Dasatinib is a potent tyrosine kinase inhibitor that is used to treat chronic myeloid leukemia in patients resistant or intolerant to imatinib mesylate. While designed to inhibit Abl and Src kinases, dasatinib shows multitarget effects, including inhibition of the macrophage colony‐stim