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Inhibition by vitamin D3 of erythroid differentiation of human leukemia line cells induced by transforming growth factor β or erythroid differentiation factor (activin A)

✍ Scribed by Junko Okabe-Kado; Yoshio Honma; Motoo Hozumi

Book ID
113239320
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
520 KB
Volume
15
Category
Article
ISSN
0145-2126

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Vitamin D and retinoids cooperate to inhibit the proliferation and induce the differentiation of human myelomonocytic U937 leukemia cells. In the present work, we investigated the role of TGF-␤ as an endogenous mediator of this process. We found that the TGF-␤1 precursor began to accumulate in cell