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Inhibition by the paf acether antagonist 48740 RP of the bronchopulmonary effects of paf-acether

✍ Scribed by S. Desquand; J. Lefort; J. Derégnaucourt; P. Sédivy; V. Lagente; J. Randon; B.B. Vargaftig

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
98 KB
Volume
7
Category
Article
ISSN
0192-0561

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Inhibition of ex-vivo PAF-induced platel
Inhibition of ex-vivo PAF-induced platelet aggregation by the PAF-antagonist RP 48740: relationship to plasma concentrations in healthy volunteers
✍ J. L. Pinquier; P. Sedivy; R. Bruno; F. Bompart; J. Gregoire; G. Strauch; J. Gai 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 469 KB

RP 48740, 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c] thiazole-7-carboxamide, a specific competitive PAF-receptor antagonist in vitro, was given to 29 healthy male volunteers for 7 days. Plasma drug concentrations and ex-vivo PAF-induced platelet aggregation were assessed on Days 1, 4, and 7. RP 48740 had l