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Inhibition by neuropeptides of interleukin-1β-induced, prostaglandin-independent hyperalgesia

✍ Scribed by R.L. Follenfant; M. Nakamura-Craig; B. Henderson; G.A. Higgs

Book ID: 117959164
Publisher: Nature Publishing Group
Year: 1989
Tongue: English
Weight: 392 KB
Volume: 98
Category: Article
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1989.tb16860.x

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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I