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Inhibition by methotrexate of the stable incorporation of 5-fluorouracil into murine bone marrow DNA

โœ Scribed by Robert C. Sawyer; Robert L. Stolfi; Daniel S. Martin; M.Earl Balis


Book ID
115781112
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
823 KB
Volume
38
Category
Article
ISSN
0006-2952

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DNA repair following incorporation of 5-
โœ John D. Schuetz; Hugh J. Wallace; Robert B. Diasio ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 313 KB

5-Fluorouracil (FUra) was previously demonstrated to be incorporated into DNA at cytotoxic concentrations in mouse bone marrow cells. Subsequently, we showed that under these conditions FUra exhibited a time-dependent removal from DNA accompanied by a decrease in DNA strand length. In the present st