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Inhibition by Colchicine of Changes in Amino Acid Transport and Initiation of DNA Synthesis in Regenerating Rat Liver

โœ Scribed by P. Roy Walker and James F. Whitfield

Book ID
123655001
Publisher
National Academy of Sciences
Year
1978
Tongue
English
Weight
795 KB
Volume
75
Category
Article
ISSN
0027-8424

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The inhibition by colchicine of the init
The inhibition by colchicine of the initiation of DNA synthesis by hepatocytes in regenerating rat liver and by cultivated WI-38 and C3H10T 1/2 cells
โœ P. Roy Walker; Alton L. Boynton; James F. Whitfield ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 949 KB

## Abstract Colchicine inhibited the initiation of DNA synthesis by hepatocytes in vivo and by WIโ€38 and C3H10T 1/2 cells in vitro. All three cell types were most sensitive to colchicine when it was administered at the time of, or shortly after, proliferative activation (by partial hepatectomy or m