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Inhibition by beraprost sodium of thrombin-induced increase in endothelial macromolecular permeability

✍ Scribed by R. Imai-Sasaki; M. Kainoh; Y. Ogawa; E. Ohmori; Y. Asai; T. Nakadate


Book ID
116163729
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
588 KB
Volume
53
Category
Article
ISSN
0952-3278

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We determined whether activation of phosphatidylinositol-specific phospholipase C (PI-PLC) and a subsequent increase in cytosolic calcium concentration ([Ca2+]i) was an obligatory signaling event mediating the increase in transendothelial permeability induced by bradykinin (BK) and alpha-thrombin (a