Inhibition and killing of fungi by the polyamine oxidase-polyamine system
β Scribed by Stuart M. Levitz; David J. DiBenedetto; Richard D. Diamond
- Publisher
- Springer Netherlands
- Year
- 1990
- Tongue
- English
- Weight
- 591 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0003-6072
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π SIMILAR VOLUMES
In a homologous series of di-guanidines (NH2C(= NH)NH(CH2)xNHC(= NH) NH2) where x = 2-12, greatest inhibition of polyamine oxidase was found with x : 8. The synthetic fungicide guazatine NH2C(= NH)NH --(CH ~)s,....~ N H NH2C(= NH)NH --(CH2)8 / was particularly effective as an inhibitor of polyamine
## Abstract The uptake and metabolism of the polyamines spermine, spermidine, cadaverine and putrescine, previously shown to potentiate heat sensitivity, were studied in cultured Chinese hamster cells. Heat (42Β°C) causes enhanced uptake of exogenously supplied polyamines into the acidβsoluble fract