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Inhibition and Activation of the Human Liver Microsomal and Human Cytochrome P450 3A4 Metabolism of Testosterone by Deployment-Related Chemicals

โœ Scribed by Usmani, K. A.

Book ID
125490595
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2003
Tongue
English
Weight
256 KB
Volume
31
Category
Article
ISSN
0090-9556

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โœ Hyun Joo; Kyoungju Choi; Randy L. Rose; Ernest Hodgson ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 200 KB

## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th