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Inhibiting the assembly of protein—protein interfaces

✍ Scribed by Reena Zutshi; Michelle Brickner; Jean Chmielewski

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
724 KB
Volume
2
Category
Article
ISSN
1367-5931

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✦ Synopsis

Protein-protein association is found throughout mechanisms of cellular growth and differentiation, and viral replication. Inhibiting the assembly of protein complexes, therefore, presents itself as a novel means of inhibition for a wide variety of cellular and viral events. Peptides and small molecules that modify the overall quaternary structure of a selection of receptor-ligand interactions and oligomeric viral enzymes have been developed recently.

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