Inhibited dissolution of drug crystals by certified water-soluble dyes III

✍ Scribed by J. Piccolo; R. Tawashi

• Book ID: 102406035
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 231 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600601209

✦ Synopsis

Results of dissolution-rate studies on diethylstilbestrol microcrystals in the presence of low concentrations of various certified water-soluble dyes are presented. Under the conditions described, marked and different degrees of inhibition were observed. Information on the dissolution inhibition process was obtained by the study of the dissolution-rate dependence on chemical group, class, and concentration of the dye. The data obtained show that cationic dyes were more reactive in lower concentration than anionic dyes and suggest higher adsorption intensity of the cationic dye molecules at the primary dissolution sources on the crystal surface.

Keyphrases

Dissolution rates-diethylstilbestrol microcrystals' inhibition by water-soluble dyes 0 Dyes, water soluble--drug crystal dissolution, inhibition 0 Diethylstilbestrol microcrystalsdissolution rates, dye inhibition 0 Crystals, diethylstilbestroldissolution rates, dye inhibition