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Inherited sex reversal in mice: Identification of a new primary sex-determining gene

✍ Scribed by Eicher, Eva M. ;Washburn, Linda L.

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
861 KB
Volume
228
Category
Article
ISSN
0022-104X

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✦ Synopsis

We present evidence that the inbred mouse strain C57BL16J (B6) differs from Mus domesticus (DOM) at a locus involved in gonad determination and development as well as at the testis-determining locus on the Y chromosome (Tdy). This newly identified gene is named testis-determining, autosomal-1 (tda-1). Although the inheritance of tda-1 suggests i t is located on an autosome, its location on the X and Y chromosome in their pairing-recombination region is not excluded. When mice are homozygous for the C57BLi6Jderived tda-1 allele (tda-lB6) and carry the Y chromosome from M domesticus, they develop as true hermaphrodites or, more rarely, as females. In contrast, when they are homozygous Tda-lDoM/Tda-lDoM or heterozygous Tda-lDoM/

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