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Inheritance of the shared epitope and long-term outcomes of rheumatoid arthritis among community-based Caucasian females

✍ Scribed by Lindsey A. Criswell; Hua Mu; Carol L. Such; Mary-Claire King

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 41 KB
Volume: 15
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1998)15:1<61::aid-gepi5>3.0.co;2-7

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✦ Synopsis

surgery for patients with 2 SE copies (OR = 3.16) reflects an average of 2 very different ORs when patients are further categorized according to genotype groups 4 and 5 (OR = 1.3 and 11.9, respectively).

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Relative predispositional effects and mode of inheritance of HLA-DRB1 alleles among community-based Caucasian females with rheumatoid arthritis

✍ Hua Mu; Mary-Claire King; Lindsey A. Criswell 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 1 views

Multiple HLA-DRB1 alleles encoding a shared epitope (SE) at amino acid positions 70-74 are associated with susceptibility to rheumatoid arthritis (RA). However, the nature of the association and the mode of inheritance differ depending upon the source of RA patients and laboratory methodology. We st