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Inheritance of mtDNA heteroplasmy: Does Kimura's solution work?

โœ Scribed by Chalkia, Dimitra; Wallace, Douglas


Book ID
122124868
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
44 KB
Volume
13
Category
Article
ISSN
1567-7249

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Leber hereditary optic neuropathy: Does
โœ Chinnery, Patrick F. ;Andrews, Richard M. ;Turnbull, Douglass M. ;Howell, Neil ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 209 KB ๐Ÿ‘ 2 views

Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch