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Inheritance of migraine investigated by complex segregation analysis

✍ Scribed by Michael Bjørn Russell; Lennart Iselius; Jes Olesen

Book ID
104666004
Publisher
Springer
Year
1995
Tongue
English
Weight
462 KB
Volume
96
Category
Article
ISSN
0340-6717

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✦ Synopsis

Migraine is the most common neurological disorder, affecting about 20% of adults. The mode of inheritance was analyzed in the two main types of migraine, migraine without aura (MO) and migraine with aura (MA), by complex segregation analysis using the computer program POINTER. We included 126 probands with MO and 127 probands with MA from the general population. First-degree relatives and spouses were blindly interviewed by a neurological research fellow. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference.

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