Inhalation Toxicology, Second Edition

✍ Scribed by Salem Harry, Sidney A. Katz

• Publisher: Informa Healthcare
• Year: 2005
• Tongue: English
• Leaves: 1055
• Edition: 2
• Category: Library

✦ Synopsis

Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects. The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures. The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge.

✦ Table of Contents

Front Cover......Page 1
Preface......Page 8
Acknowledgments......Page 10
About the Editors......Page 12
Contributors......Page 14
Contents......Page 18
1. Inhalation Risk Assessment at the Environmental Protection Agency......Page 24
2. The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances......Page 60
3. Emergency Response Planning Guidelines (ERPGs)......Page 82
4. Directed-Flow Aerosol Inhalation Exposure Systems: Applications to Pathogens and Highly Toxic Agents......Page 94
5. Low-Level Effects of VX Vapor Exposure on Pupil Size and Cholinesterase Levels in Rats......Page 112
6. Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example......Page 130
7. The Use of Large Animals in Inhalation Toxicology......Page 140
8. Toxic Load Modeling......Page 158
9. Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program......Page 180
10. Toxicology of Fire and Smoke......Page 226
11. Toxicogenomics of Low-Level Nerve Agent Vapor Exposure......Page 252
12. Respiratory Sensitization......Page 264
13. Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure......Page 290
14. Role of Cytokines in Pulmonary Infl ammation and Fibrosis Induced by Inhaled Mineral Particles......Page 328
15. Hormesis: Implications for Risk Assessment......Page 356
16. Nasal Toxicology......Page 370
17. Effects of Inhaled Toxicants on the Nose and Nasal Function......Page 394
18. Toxicokinetics: Deposition, Absorption, Distribution, and Excretion......Page 426
19. Mechanistic Determinants and Modeling of the Inhalation Pharmacokinetics of Volatile Organic Chemicals......Page 460
20. Inhalation Toxicology of an Irritant Gas—Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure......Page 478
21. Inhalation Toxicology of Riot Control Agents......Page 506
22. Chemical Warfare Agents and Nuclear Weapons......Page 542
23. The Inhalation Toxicology of Chromium Compounds......Page 564
24. Safety Assessment of Therapeutic Agents Administered by the Respiratory Route......Page 586
25. Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract......Page 630
26. Inhalation Toxicology of Alcohol/Gasoline Fuels—Current Status......Page 644
27. Asbestos......Page 668
28. The Inhalation Toxicity of Benzene......Page 690
29. Carbon Monoxide......Page 716
30. Experimental, Clinical, Occupational Toxicology, and Forensic Aspects of Hydrogen Cyanide with Particular Reference to Vapor Exposure......Page 738
31. The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans......Page 824
32. Fluorocarbon Alternatives—Methodologies for Special Studies and Results......Page 846
33. Animal Models for Three Major Cigarette-Smoke-Induced Diseases......Page 872
34. The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health......Page 896
35. Health Aspects of Bioaerosols......Page 934
36. Emerging Biothreats: Natural and Deliberate......Page 954
37. Toxicology Associated with Respiratory Exposures to Fungi (Molds)......Page 966
38. Inhalation Toxicity of Botulinum Neurotoxin......Page 984
39. Inhalation Ricin: Aerosol Procedures, Animal Toxicology, and Therapy......Page 994
40. Toxicity, Mechanisms, Prophylaxis, and Therapy of Inhaled Biological Toxins......Page 1004
Index......Page 1038

✦ Subjects

Медицинские дисциплины;Токсикология;