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Inhalation exposure of rats to metal aerosol. I. Effects on pulmonary surfactant and ascorbic acid

✍ Scribed by Zuzana Kováčiková; Darina Chorvatovičová

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
215 KB
Volume
12
Category
Article
ISSN
0260-437X

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✦ Synopsis

Female albino Wistar rats were exposed to 4 pm particles separated from nickel refinery waste. The generated aerosol of 50 mg m-3 mainly consisted of metal oxides, the most toxic being NiO and Cr,03. The exposure of 5 h per day, 5 days per week, lasted for 4 weeks or 4 months. At the end of the exposure period the amounts of pulmonary surfactant and ascorbic acid were estimated in both exposed and control rats. The amount of pulmonary surfactant was elevated after both exposure times, while ascorbic acid increased significantly ( P < 0.02) only after 4 weeks of exposure.

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