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ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells

✍ Scribed by Xin Zhang; Lu-Sheng Xu; Zhi-Qin Wang; Ke-Sheng Wang; Na Li; Zhi-Hong Cheng; Shang-Zhi Huang; Dong-Zhi Wei; Ze-Guang Han


Book ID
116464604
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
373 KB
Volume
570
Category
Article
ISSN
0014-5793

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh