Infusion of GAT1-saporin into the medial septum/vertical limb of the diagonal band disrupts self-movement cue processing and spares mnemonic function

Impaired and spared cholinergic function

Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin

✍ Qing Chang; Paul E. Gold 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB

## Abstract To lesion the cholinergic input to the hippocampus, rats received injections of 192 IgG‐saporin into the medial septum/vertical limb of the diagonal band (MS/VDB). The lesions produced near‐total loss of choline acetyltransferase (ChAT)‐positive neurons in the MS/VDB. The loss was accom