Mutations in mitotic checkpoint genes have been detected in several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from chromosomal instability and have been reported in many lung cancers. To determine whether alteration of mitotic checkpoint re
โฆ LIBER โฆ
Infrequent Somatic Mutation of the MTS1 Gene in Primary Bladder Carcinomas
โ Scribed by Kai, Mikio ;Arakawa, Hirofumi ;Sugimoto, Yoshihisa ;Murata, Yasushi ;Ogawa, Michio ;Nakamura, Yusuke
- Book ID
- 108581077
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 342 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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## Background: The authors examined somatic mutations of the adenomatous polyposis coli (apc) gene in 84 human aberrant crypt foci (acf) to determine whether apc gene mutations were involved in the histologic progression of acf. ## Methods: Mutation cluster regions of the apc gene were subjected
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