𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Informativeness of twin-nuclear family and nuclear family designs for segregation analysis

✍ Scribed by Dr. David L. Duffy; Lindon J. Eaves; G. P. Vogler

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
247 KB
Volume
8
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

This brief note examines the precision of segregation parameter estimates from both twin-nuclear family and conventional nuclear family designs. The program MENDEL was used to derive expected frequencies of different family patterns of affectation (with fixed sibship size) under various single gene models, and then to estimate the standard errors (and information) associated with gene frequency and penetrance values at given sample sizes. As might be expected, a 2- to 5-fold increase in relative efficiency was found for the same family size if families included an MZ twin pair among their offspring. The methods used allow convenient calculation of expected informativeness of a given study design.

πŸ“œ SIMILAR VOLUMES

The resolution of genotype Γ— environment
The resolution of genotype Γ— environment interaction in segregation analysis of nuclear families
✍ Dr. Lindon J. Eaves; D. C. Rao πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 945 KB

A model is presented for the effects of one or two loci, a measured index of the environment and genotype X environment (G X E) interaction of risk for a discontinuous trait. Initial properties of the model are explored for the single locus case, with and without the effects of environment and GXE i

Segregation analysis of quantitative tra
Segregation analysis of quantitative traits in nuclear families: Comparison of three program packages
✍ Lyle W. Konigsberg; Candace M. Kammerer; Jean W. MacCluer; D. C. Rao; G. P. Vogl πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 813 KB

Segregation analysis frequently is used to test for the presence of major gene effects and to estimate the various genetic and environmental components contributing to diseases. Recent advances in both theoretical models and computational algorithms have provided a number of new programs for perform

Haplotype association analysis for late
Haplotype association analysis for late onset diseases using nuclear family data
✍ Chun Li; Michael Boehnke πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 208 KB πŸ‘ 1 views

## Abstract In haplotype‐based association studies for late onset diseases, one attractive design is to use available unaffected spouses as controls (Valle et al. [1998] Diab. Care 21:949–958). Given cases and spouses only, the standard expectation‐maximization (EM) algorithm (Dempster et al. [1977

Gibbs sampling–based segregation analysi
Gibbs sampling–based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear families
✍ Lyle J. Palmer; William O.C.M. Cookson; Alan L. James; A. William Musk; Paul R. πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 102 KB

Asthma is a common, complex human disease. Elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts, and increased airway responsiveness are physiological traits that are characteristic of asthma. Few studies have investigated major gene effects for these traits in a population

Genetic analysis of human breast cancer:
Genetic analysis of human breast cancer: Implications for family study designs
✍ Nadine Andrieu; Dr. Florence Demenais; Maria Martinez; D. C. Rao πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 640 KB

Genetic analysis of human breast cancer, as with many common diseases, raises several problems including sampling strategies, genetic heterogeneity, and geneenvironment interactions. A reanalysis of 200 Danish breast cancer pedigrees, under the unified mixed model, was conducted to investigate more