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Influenza in children and young adults with cancer. 20 cases

✍ Scribed by Sandor Feldman; Robert G. Webster; Martha Sugg

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
347 KB
Volume
39
Category
Article
ISSN
0008-543X

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✦ Synopsis

The purpose of this study was to characterize the clinical features of laboratoryconfirmed influenza in 20 children and young adults with cancer who were receiving immunosuppressive therapy. Viruses isolated from pharyngeal and nasopharyngeal cultures were identified as the A/Hong Kong/l/68 strain or one of its variants, either A/England/42/72, A/Port Chalmers/l/73, or A/Victoria/3/75. Although the signs and symptoms of influenza in our patients were not unusual, the clinical course lasted twice as long as i n the general population. Complications developed in only 3 patients and were related to secondary bacterial infections rather than influenza. An important sequelae of influenza was the interruption of cancer therapy in 16 patients for periods of 4 days to 3 '/z weeks. The severity of influenza did not appear related to type or activity of malignancy or to duration or specific form of cancer therapy. Guidelines for the prevention and management of influenza in children with cancer are recommended.

Cancer 39:350-353, 1977.

ERTAIN VIRAL INFECTIONS-NOTABLY THOSE

C caused by varicella-zoster,6"' Herpes virus hominis, 1s,14 cytomegalovirus, and rubeola, 'are more severe and often fatal in patients with impaired immune responses. Other viruses such as rhinovirus, adenovirus, and enterovirus cause essentially the same frequency and severity of infection in patients with cancer as in the general population." Although responsible for periodic epidemic, influenza virus infection has not been systematically studied in children with cancer. During the influenza epidemics of 1957 to 1966, Housworth and Langmuir' reported higher mortality rates for patients with malignant neoplasms than for otherwise normal people. At least two fatal cases of influenza have been described in From the Infectious Diseases Service and the

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