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Influenza A virus derived from persistently virus-infected cells shows attenuated cytotoxicity in cultured cells but virulent pathogenicity in mice

✍ Scribed by Md. Jaber Hossain; Isamu Mori; Beixing Liu; Yoshinobu Kimura

Book ID
116748489
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
407 KB
Volume
44
Category
Article
ISSN
0882-4010

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Evaluation of a virus derived from MDCK
Evaluation of a virus derived from MDCK cells infected persistently with influenza A virus as a potential live-attenuated vaccine candidate in the mouse model
✍ Beixing Liu; Md. Jaber Hossain; Isamu Mori; Yoshinobu Kimura 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

## Abstract A temperature‐sensitive mutant virus unable to replicate at 38°C was recovered from passage 189 (IVpi‐189) of Madin‐Darby canine kidney cells infected persistently with influenza A. Immunofluorescent staining of the IVpi‐189 virus‐infected cells revealed disrupted transport of the matri