Influence of water on the chromic anhydride Oxidation of androstenolone acetate.

✍ Scribed by C.M. Hol; M.G.J. Bos; H.J.C. Jacobs

• Book ID: 104239155
• Publisher: Elsevier Science
• Year: 1969
• Tongue: French
• Weight: 96 KB
• Volume: 10
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)87828-x

✦ Synopsis

In 1952 St. Andre et al1 described the preparation of 3&acetoxy-1@-hydroxyandrost-5-en-17_one

(2) from 3P-acetory-androst-5-en-17-one (1) by chromic anhydride oxidation of the dibromide in acetic acid. This reaction haa since been extensively used for the direct introduction of an a-hydroxyl group at C-14 in the steroid nucleus 293. In a recent paper Sykes and Kelly3 report that