GATA-3 is a zinc-finger transcription factor that is essential for both early T cell development and Th2 cell differentiation. To quantify GATA-3 expression during T cell development in vivo in the mouse, the GATA-3 gene was targeted by insertion of a lacZ reporter by homologous recombination in emb
✦ LIBER ✦
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
✍ Scribed by Luci, Carmelo; Reynders, Ana; Ivanov, Ivaylo I; Cognet, Celine; Chiche, Laurent; Chasson, Lionel; Hardwigsen, Jean; Anguiano, Esperanza; Banchereau, Jacques; Chaussabel, Damien
- Book ID
- 109920741
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 877 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni.1681
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Background. Recent results suggest that some PKC isotypes, when overexpressed, confer to cultured fibroblasts certain proliferative advantages, and enhanced tumorigenicity in nude mice, suggesting their participation in carcinogenic processes. These findings need to be validated through the investig