Influence of the strain of rats on the induction of hexachlorobenzene induced porphyria
✍ Scribed by Rosa Wainstok De Calmanovici; Silvia C.Billi De Catabbi; Carmen A. Aldonatti; Leonor C.San Martín De Viale
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 703 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0020-711X
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## Abstract Uroporphyrinogen decarboxylase is an essential enzyme in all organisms and functions in the heme biosynthetic pathway, catalyzing the decarboxylation of the four acetate groups of uroporphyrinogen to form coproporphyrinogen. This work examines whether the four sequential decarboxylation
Male C57Bl/10 mice were chronically fed hexachlorobenzene (HCB) (0.02% of the diet) alone or in combination with a single subcutaneous dose of iron (12.5 mg iron per mouse). After eight weeks the group of mice pretreated with the iron overload was highly sensitized to the porphyrogenic effect of HCB