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Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine

✍ Scribed by Jin-Heng Li; Jing-Qiu Xu; Xiao-Mei Cao; Li Ni; Yong Li; Yi-Yi Zhuang; Jian-Bin Gong

Book ID
117074533
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
130 KB
Volume
317
Category
Article
ISSN
0009-8981

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## Abstract Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the admini