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Influence of the organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer

✍ Scribed by Han, Ji-Youn; Lim, Hyeong-Seok; Shin, Eun Soon; Yoo, Yeon-Kyeong; Park, Yong Hoon; Lee, Jong-Eun; Kim, Heung Tae; Lee, Jin Soo


Book ID
119319727
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
207 KB
Volume
59
Category
Article
ISSN
0169-5002

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## Abstract ## BACKGROUND. The authors investigated whether __ABCB1, ABCC2,__ and __ABCG2__ genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC). ## METHODS. Blood samples from 107 NSCLC patients treate