Influence of the Nucleophile on the Candida antarctica Lipase B-Catalysed Resolution of a Chiral Acyl Donor
✍ Scribed by Eduardo García-Urdiales; Nicolás Ríos-Lombardía; Juan Mangas-Sánchez; Vicente Gotor-Fernández; Vicente Gotor
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 537 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1439-4227
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Lipase B from Candida antarctica (CAL-B) catalyses the highly enantioselective (E > 200) transesterification of some 1-biaryl-2-yl-, -3-yl-, and -4-ylethanols and -propan-1-ols, as well as 1-(o-, m-, and p-pyridylphenyl)ethanols, 6, with vinyl acetate, Kazlauskas rule being obeyed in all cases. meta
## Abstract The selectivity of acetylation of δ‐functionalized secondary alcohols catalyzed by __Candida antarctica__ lipase B has been examined by molecular dynamics. The results from the simulation show that a δ‐alcohol functionality forms a hydrogen bond with the carbonyl group of Thr 40. This i
The lipase-catalyzed enantioselective esterification of ibuprofen has been studied in a media, composed only of substrates. When racemic ibuprofen is used, the alcohol-chain length affects the esterification rates of individual enantiomers, but it does not affect the enantioselectivity. Water activi