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Influence of the menstrual cycle on aminolevulinic acid induced protoporphyrin IX fluorescence in the endometrium: In vivo study

✍ Scribed by Andrea Degen; Tanja Gabrecht; Georges Wagnières; Rosmarie Caduff; Bruno Imthurn; Pius Wyss

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
57 KB
Volume
36
Category
Article
ISSN
0196-8092

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✦ Synopsis

Background and Objectives: In vitro studies indicated that compared to postmenopausal women, premenopausal women had increased aminolevulinic acid induced protoporphyrin IX (ALA-induced PpIX) fluorescence expression in the endometrium. The aim of this study was to evaluate menstrual cycle dependency of ALA-induced PpIX fluorescence in the endometrium in vivo. Study Design/Patients and Methods: Thirteen patients were included for in vivo spectrofluorometric measurements of ALA-induced PpIX in the endometrium and 51 patients for fluorescence hysteroscopy. Two milliliter of a 2% 5-ALA-solution at pH ¼ 4.0 (ASAT AG/Zug, Switzerland) was topically administrated just before spectrofluorometry and 4 hours before hysteroscopy. Spectrofluorometry: Optical fiber based. Fluorescence hysteroscopy:

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