Influence of the conformation of amide analogs of acetylcholine on their cholinomimetic activity
โ Scribed by N. V. Khromov-Borisov; L. N. Aleksandrova; A. F. Danilov; S. A. Shelkovnikov
- Book ID
- 112407210
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 237 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0091-150X
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๐ SIMILAR VOLUMES
A few years ago Potapov and Terent'ev showed' that the rotatory dispersion curve of amide is related to the polarity of the solvent./In bensene the curve is positive and in methanol negative./ This solvent effect was interpreted as the demonstration of tautomerism:
We have prepared three conformationally restricted analogs of DuP753 in which one of the phenyl rings in the biphenyl moiety is fused to the imidazole ring, and have investigated the conformation-biological activity relationship of these compounds. Conformational analysis on DuP753 and these compoun